Nanoporous metal oxide surface for stronger bioceramic coated implants.


Dr. Krishnan Raja of the University of Idaho and Dr. Mano Misra of the University of Nevada, Reno have developed a method for forming a bioceramic-coated apparatus. This coating is designed with nanopores to increase the tensile strength a bioceramic coating.

Technology Summary

Bioceramics are ceramic materials designed to be biocompatible—that is, to exist inertly and without rejection when implanted into an organism. Their primary uses are medical: usually, apparatuses designed as surgical implants (artificial teeth, bones, pacemakers, etc.) must be either composed of or coated in bioceramic materials, to avoid rejection by the host. Bioceramics are subdivided by their activity in the body: bioinert materials are non-toxic, resilient, and designed to carry on indefinitely. Bioactive materials actually react with the body itself to integrate more naturally. One bioactive bioceramic, hydroxyapatite (HA), exists within human bones and teeth, and interacts with an implant site to support bone ingrowth and osseointegration. Previous methods for applying HA coatings have included RF sputtering, electrochemical deposition, and plasma spray. However, these methods have been characterized by non-uniform coating and microscopic cracks and defects. The present technology uses a metal (e.g. Ti) substrate with a nanoporous metal oxide surface to anchor the bioceramic coating (e.g. HA). A method is also provided for producing this system: the metal substrate is anodized in a fluoride-phosphoric acid solution to create the oxide surface and introduce phosphate ions to the interior of that surface, and the bioceramic is electrodeposited on. Creating a nanoporous surface helps obviate the microscopic defects and problems inherent in other methods.

Potential Applications

  • Orthopedic: Bone repairs, reinforcements, or grafts
  • Dental: Tooth replacements, fillings, and repairs
  • Bone-integrated or bone “disguised” electronic devices including pacemakers, ICDs, dialysis machines, respirators, etc.
  • Permanent prosthetic limbs attached seamlessly by artificial bone
  • Bioactive knee and hip replacements
  • Stents


The University of Nevada, Reno is seeking expressions of interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology.

IP Status

UNR ID#: UNR04-035
“Bioceramic coated apparatus and method of forming the same”
US Patent: No. 7,998,568

Patent Information:
For Information, Contact:
Shannon Sheehan
Manager, Technology Commercialization
University of Nevada, Reno
Krishnan Raja
Shantanu Namjoshi
Manoranjan Misra
Kamrakali Paramguru
Archana Kar