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Visual Compensation and Diagnostic for Central Vision Loss
Age-related degenerative eye diseases, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, are common eye conditions that leads to irreversible vision loss among people over 50. These diseases cause damage to the macula, retina or the optic nerve, and advance slowly. Current treatments only attempt to slow the progression of...
Published: 5/8/2020
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Updated: 5/8/2020
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Category(s): Healthcare & Pharmaceuticals, Software
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Two novel therapeutic candidates for the treatment and reversal of various morbidities associated with diabetes mellitus, obesity, and gastrointestinal motility disorders.
BACKGROUND
According to data from the World Health Organization, there are over 425 million diabetic patients in the world, and that number has been rapidly increasing as the prevalence of obesity also increases. Obesity and diabetes are closely interconnected as 90% of diabetics are also obese. People with type 1 diabetes (T1D) don’t produce...
Published: 5/5/2020
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Updated: 5/5/2020
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Inventor(s): Seungil Ro
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Category(s): Healthcare & Pharmaceuticals
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Cyclic dominant negative competence stimulating peptide analogs to treat Streptococcus pneumoniae infections
Background
Streptococcus pneumoniae (pneumococcus) is a bacterial pathogen responsible for many diseases in humans including pneumonia, meningitis, sepsis, and otitis media. It is a prevalent source of health and economic burden, with a death toll of >22,000 a year and >$3.5 billion in direct medical costs in the US alone. Concerns for current...
Published: 5/7/2020
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Updated: 4/22/2020
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Category(s): Healthcare & Pharmaceuticals
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Lateral Flow Immunoassay (LFI) for the Rapid Diagnosis of Plague
BackgroundIn the 14th century, plague was the cause of a pandemic wiping out 60% of Europe’s population. The bacterium responsible, Yersinia pestis, utilizes wild rodents as a natural reservoir and is primarily transmitted by fleas to other animal and human hosts. If administered early, antibiotics are effective at treating plague, but delayed...
Published: 4/23/2020
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Updated: 12/16/2019
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Category(s): Healthcare & Pharmaceuticals
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Antigen Detection Assay for Early Point-of-Care Diagnosis of Zaire ebolavirus
Background The Ebola virus (EBOV) outbreak in West Africa from 2013 to 2016 and the multiple outbreaks in Democratic Republic of the Congo during 2018 have highlighted the need for a sensitive and rapid EBOV diagnostic test. Ideally, an EBOV Rapid test allows for point-of-care (POC) screening of patients and offers reliable sensitivity to support earlier...
Published: 5/7/2020
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Updated: 12/16/2019
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Category(s): Healthcare & Pharmaceuticals
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Compositions acting as (pro)renin receptor antagonists for the treatment of non-alcoholic fatty liver disease
BackgroundNon-alcoholic fatty liver disease (NAFLD) is an umbrella term for a range of liver conditions where excess fat is stored in the liver, and affects people with little to no alcohol use. Non-alcoholic steatohepatitis (NASH) is a potentially serious form of the disease that includes liver inflammation and potential scarring, cirrhosis, and liver...
Published: 4/23/2020
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Updated: 12/10/2019
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Inventor(s): Yumei Earley
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Category(s): Healthcare & Pharmaceuticals, Chemical
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Methods of Treating Muscular Dystrophy
BackgroundDuchenne muscular dystrophy (DMD) affects 1 in 3500 live male births with patients suffering from chronic muscle degeneration and weakness. Clinical symptoms are first detected between the ages of 2 and 5 years and, by the time the patient is in their teens, the ability for independent ambulation is lost. Death typically occurs in the patient...
Published: 4/10/2020
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Updated: 12/10/2019
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Inventor(s): Dean Burkin, Ryan Wuebbles, Praveen Gurpur, Stephen Kaufman
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Category(s): Healthcare & Pharmaceuticals
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Administration of Nootropic Agents for Enhancing Neuroprotective Signaling in Parkinson’s Disease
BackgroundParkinson’s Disease (PD) is a chronic, neurodegenerative disease, caused by the progressive loss of midbrain dopamine neurons in the substantia nigra, which sends axons to the striatum. Approximately 1% of Americans are afflicted with PD, which give rise to more than $14 billion in medical-related costs each year. Symptoms include irreversible...
Published: 4/23/2020
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Updated: 10/2/2018
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Category(s): Healthcare & Pharmaceuticals, Life Sciences
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Use of in vivo Microbial Antigen Detection (InMAD) with human biological fluids for detection of circulating antigens
BackgroundDiagnosis of an infection in a timely manner is essential for proper therapeutic administration and more effective treatments, especially for diseases with non-specific early symptoms. Acute infections are typically diagnosed by identifying microbial antigens directly from patient samples. However, microbes do not replicate to high levels...
Published: 4/20/2020
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Updated: 8/16/2018
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Inventor(s): David AuCoin, Thomas Kozel, Claire Smalley
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Category(s): Biotechnology, Healthcare & Pharmaceuticals, Life Sciences
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Development of Melioidosis Subunit Vaccines
Background:Burkholderia psuedomallei , the etiologic agent of melioidosis, causes severe disease in both humans and animals. Melioidosis is an emerging bacterial infectious disease that is being increasingly recognized in tropical regions around the world. Diagnosis and treatment of melioidosis can be challenging and no commercial vaccines currently...
Published: 4/23/2020
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Updated: 6/29/2018
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Inventor(s): Paul Brett
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Category(s): Healthcare & Pharmaceuticals
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